Endocrine Abstracts

Objetive: Obesity is associated with lower serum vitamin D (25(OH)D3) levels through several mechanisms. The aim of the study was to determine the prevalence of vitamin D deficiency and to examine the association between insulin resistance and 25(OH)D3 levels in a cohort of obese subjects.Materials and methods: 85 obese subjects were enrolled into the study from october to december 2018. Demographic, anthropometric and clinical para...

Introduction: Flash glucose monitoring (FGM) allows non-invasive glucose level assessment. Studies have shown that patients using FGM test their glucose levels more often than those who use traditional blood glucose testing. Given that a higher rate of glucose testing has showed to improve glycemic control our objective was to describe the change in the glycemic control and time in euglycemic range in patients with FGM and the effect of the number of scans in this control....

Objective: To evaluate the baseline characteristics and their evolution three months after implantation of the Flash glucose monitoring System (Freestyle Libre), after financing by the Andalusian Health Service in patients under 18 years old with type 1 diabetes mellitus (DM1) in our hospital area.Material and Methods: A descriptive observational and retrospective study that includes patients with DM1 under 18 years old from the southern hospital area of...

Objectives: Assess the canagliflozin effect on the ABPI in patients without previous treatment with iSGLT-2 as a possible etiology of tissue hypoperfusion and a risk factor for amputations.Material and methods: Prospective observational study where we analyzed patients diagnosed of type 2 diabetes mellitus (DM2) with poor metabolic control and without prior treatment with iSGLT-2, which is initiated treatment with canagliflozin. Clinical, biochemical par...

Clinical case: A 19-year-old male came to the Emergency Department complaining about a holocraneal nonpulsatile headache growing in intensity for the last 3 h, unresponsive to common analgesics. He had been suffering anxiety sleep deprivation, nervousness, tremor and heart palpitations for the last week. Family history was irrelevant, and the patient had no history of hypertension, dyslipidaemia, diabetes or smoking or medication use; he reported moderate alcohol, coffee and e...

A 27-year-old male without relevant familial or personal history had three TIAs in the last year, lasting for about 20 min with partial right palsy and aphasia. By the time he was cared for in the Emergency Department. he had already recovered; his lab tests, chest X-ray and EKG were normal but his BP was high (PAS 170–190 mmHg, PAD 105–120 mmHg). He had no chest pain, headache or neurovegetative symptoms. On discharge the patient was treated with manidipine and ASA ...

Clinical Case: A 39-year-old woman was referred to our Hypertension Clinic for workup after three episodes of TIA with SBP >180 mmHg in the last 6 months. Diagnosed and treated of hypertension and hypokaliemia since she was 15 years old, no secondary cause had been searched. She was treated with Telmisartan/Amlodipine/Hydrochlorothiazide 80/10/25 mg plus Carvedilol 12.5 mg BID and potassium supplements. She had no history of diabetes or dyslipidemia and did not smoke. Heig...

Clinical Case: A hypertensive 60-year-old woman with nephroangiosclerotic stage IV chronic renal failure (eGFR 23.44 ml/min/1.73 m2) was referred to our hypertension clinic after the CT finding of a 26-mm left adrenal mass with adenoma density during hypertension workup, with normal right adrenal. Physical exam was unremarkable except for BP 167/98 mmHg. Plasma aldosterone was 353 ng/ml, PRA 1.3 ng/ml/h, ratio 90.2, K+3.1 mEq/l, and metanephrines were nor...

A 49-year-old male was referred to our Hypertension Clinic with uncontrolled hypertension, treatment Valsartan/Amlodipine/Hydrochlorothiazide 80/10/25 mg + Doxazosine 4 mg. Mean home BP was 156/103 mmHg. Personal history: dyslipidaemia, central obesity and type 2 diabetes, with mild diabetic retinopathy, persistent microalbuminuria and preserved renal function. Treatment: Metformin/Sitagliptin 1000/50 mg BID; Pravastatin/Fenofibrate 40/160 mg. Height 172 cm, weight 112 kg, BMI...

Objectives: The AMANDHA randomized study (PROBE design) showed that the addition of Manidipine 20 mg vs Amlodipine 10 mg for 2 years in 91 hypertensive type 2 diabetic patients with persistent microalbuminuria, uncontrolled with a renin-angiotensin system inhibitor (given full-dose for at least the 6 previous months) was more effective in reducing albuminuria in spite of similar blood pressure control. Patients with significant renal impairment (PlCr >1.4 mg/dl in women an...